Expression and V(D)J recombination activity of mutated RAG-1 proteins

View Full Paper

Ask AI

Bookmark

Population

Mouse RAG-1 gene expression system

Design

Preclinical

Authors

Discussion

No immediate clinical implications; leaves open whether RAG-1 truncations affect immune development or editing strategies in vivo.

Population

Mouse RAG-1 gene expression system

Intervention

Mutagenesis (large deletions, small deletions, and specific peptide sequence changes) of the RAG-1 gene

Outcome

V(D)J recombination activity and protein transport to the nucleussurrogate

Significant portions of the RAG-1 protein are not required for its V(D)J recombination activity or nuclear transport.

Sadofsky et al. (1993) studied this question.

View Full Paper

Ask AI

Bookmark