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The two children who form the subject of this paper were shown at the Section for the Study of Disease in Children of the Royal Society of Medicine on March 25, 1938, when it was considered that they were examples of a previously undescribed condition (Freeman and Sheldon, 1938). Both cases exemplify a number of similar features, and as there can be little doubt that these go together to form one disease entity, a full account is offered in view of the fact that this appears to be its first description.
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Freeman et al. (1938) studied this question.
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