Key result
Contrast volume ≥ 100 ml increased the risk of contrast-induced nephropathy compared to lower volumes in patients undergoing coronary intervention.
Why the study?
Contrast-induced nephropathy frequently occurs after cardiac catheterization or PCI, making it important to identify risk factors affecting its occurrence in patients undergoing coronary intervention.
Cohort (n=50)
No
Pre-procedural serum creatinine > 1.5 mg/dl and contrast volume ≥ 100 ml are significant risk factors for the development of contrast-induced nephropathy in patients undergoing coronary intervention.
Answers are grounded in this paper and cite their sources.
May support minimizing contrast volume in coronary interventions; leaves open need for RCTs to confirm causality.
Background: Contrast-induced nephropathy (CIN) is a manifestation of acute kidney injury (AKI) that occurs after exposure to intravascular contrast media. This often occurs after cardiac catheterization or percutaneous coronary intervention (PCI). So it is important to know what risk factors can affect the occurrence of CIN in patients undergoing coronary intervention. Objective: To determine the relationship of CIN risk factors to the incidence of CIN in patients undergoing coronary intervention. Methods: Prospective cohort study of 50 patients undergoing coronary intervention at Sanglah Hospital in January - June 2019. Analysis bivariate using the chi square, if the condition is not fulfilled, analyze using Fisher test. Then, multivariate analysis with logistic regression was performed. Data analysis using SPSS software version 24.0. Result: Of the 50 patients who underwent coronary intervention as many as 7 people experienced CIN. Risk factors that were statistically significant related to the incidence of CIN, including serum creatinin levels before treatment (RR, 1,53; 95% CI, 1,11-2,12; p = 0,001), and amount of contrast (RR, 6,074; 95% CI, 1,64-22,54; p = 0,015). Multivariate analysis with probability of CIN in patients with contrast ≥ 100 ml and serum creatinine> 1.5 (p = 66%). Conclusion: there was a statistically significant relationship between serum creatinin levels and the amount of contrast with the incidence of CIN in patients undergoing coronary intervention.
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Kandarini et al. (2021) conducted a cohort in Contrast-induced nephropathy (n=50). Contrast volume ≥ 100 ml vs. Contrast volume < 100 ml was evaluated on Incidence of contrast-induced nephropathy (CIN) (RR 6.074, 95% CI 1.64-22.54, p=0.015). Contrast volume ≥ 100 ml increased the risk of contrast-induced nephropathy compared to lower volumes in patients undergoing coronary intervention.
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