Why the study?
Does losartan improve renal outcomes compared to verapamil in a rat model of chronic renal failure?
Population
Male WKY rats with chronic renal failure (1 month after five-sixths nephrectomy)
Comparison
Losartan treated for 2 months vs Verapamil treated for 2 months
Design
Preclinical
Follow-up
2 months
Authors
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Suggests BP-independent renoprotection with losartan in rat CKD models; leaves open translation to human trials.
Does losartan improve renal outcomes compared to verapamil in a rat model of chronic renal failure?
In a rat model of chronic renal failure, losartan provided renoprotective effects independent of blood pressure reduction when compared to verapamil.
Eliahou et al. (2001) studied this question.
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