Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation.

Rats with 5/6 renal mass ablation (n=40)

Enalapril (25 and 40 mg/L), losartan (180 mg/L), or a combination of enalapril (25 mg/L) + losartan (180 mg/L) for 12 weeks

Vehicle

Systolic blood pressure, urinary protein excretion rate, and histological evidence of focal and segmental glomerulosclerosis and hyalinosis (FSGS) and interstitial fibrosis at 12 weekssurrogate