Key result
Proximal coronary sinus overdrive pacing during an electrophysiological study repeatedly induced prolonged ventricular asystole in a 40-year-old man with a history of vasovagal syncope.
Why the study?
Prolonged ventricular asystole induced by low-frequency proximal coronary sinus overdrive pacing has rarely been reported.
Case Report (n=1)
No
Low frequency proximal coronary sinus overdrive pacing can induce prolonged ventricular asystole, likely representing a vagally mediated atrioventricular block.
Should not change syncope evaluation protocols; hypothesis-generating for coronary sinus pacing as a vagal trigger.
BACKGROUND: Atrioventricular node (AVN) is an interatrial septum structure located at the apex of triangle of Koch that modulates the transmission of impulses from atria to the ventricles. Vagally mediated AVN block with high frequency stimulation (HFS) was investigated in a few animal and human studies, but prolonged ventricular asystole that was induced by a low frequency proximal coronary sinus (CS) overdrive pacing has rarely been reported. CASE REPORT: A 40-year-old man was admitted in our hospital for evaluation of syncope and palpitation. He presented with prolonged ventricular asystole by proximal CS pacing during electrophysiological study (EPS). CONCLUSION: There is no comprehensive clinical study to investigate the association of vasovagal syncope with vagally mediated atrioventricular block (AVB) which is induced by posteroseptal area stimulation. Radiofrequency catheter ablation of ganglionated plexi (GP) located close to sinus node and AVN was reported to eliminate the vagal efferent output during vasovagal syncope as a new treatment strategy.
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Madadi et al. (2021) conducted a case report in Syncope and palpitation (n=1). Proximal coronary sinus overdrive pacing was evaluated on Prolonged ventricular asystole. Proximal coronary sinus overdrive pacing during an electrophysiological study repeatedly induced prolonged ventricular asystole in a 40-year-old man with a history of vasovagal syncope.
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