Key result
Cardioneuroablation linked to a ~20 bpm heart rate increase in patients with cardiogenic syncope.
Why the study?
Pacing therapy is indicated for symptomatic bradyarrhythmia but is not a radical cure, prompting evaluation of restricted ablation of parasympathetic innervation surrounding sinus and AV nodes.
Does cardioneuroablation improve electrophysiological parameters and prevent symptom recurrence in patients with cardiogenic syncope?
Population
13 patients with cardiogenic syncope
Design
Single-arm feasibility study
Follow-up
Mean of 13.0 ± 5.9 months
Authors
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Supports feasibility of cardioneuroablation in cardiogenic syncope; leaves open efficacy for symptom prevention in prospective trials.
Does cardioneuroablation improve electrophysiological parameters and prevent symptom recurrence in patients with cardiogenic syncope?
Absolute Event Rate: 69% vs 49%
p-value: p=0.008
Cardioneuroablation of parasympathetic innervation surrounding the sinus and AV nodes is feasible and significantly improves heart rate and electrophysiological parameters in patients with cardiogenic syncope.
Lu et al. (2019) studied Paroxysmal bradyarrhythmia and cardiogenic syncope (n=13). Cardioneuroablation vs. Pre-ablation baseline was evaluated on Heart rate (beats/min) (p=0.008). Cardioneuroablation significantly increased heart rate from 49.0 to 69.0 beats/min (P=0.008) and shortened sinus node recovery time in patients with cardiogenic syncope.
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