Key result
Patients with a history of type 2 diabetes for over 10 years had a higher prevalence of cardiovascular autonomic impairment (30.76%) compared to newly diagnosed patients (7.69%).
Why the study?
Diabetic autonomic neuropathy is a major complication of diabetes mellitus that occurs in most patients, prompting screening and diagnosis of latent cases across different disease durations.
Does a longer duration of type 2 diabetes mellitus (>10 years) increase the prevalence of autonomic neuropathy compared to newly diagnosed diabetes?
Cross-Sectional (n=104)
Single-blind
No
Does a longer duration of type 2 diabetes mellitus (>10 years) increase the prevalence of autonomic neuropathy compared to newly diagnosed diabetes?
Cardiac autonomic dysfunction is significantly more prevalent in patients with a longer history of type 2 diabetes (>10 years) compared to newly diagnosed patients.
Longer type 2 diabetes duration was associated with autonomic impairment; hypothesis-generating and requires prospective validation before any screening change.
Introduction: Diabetic autonomic neuropathy is one of the most important complications of diabetes mellitus (DM) that ultimately occurs in most patients. The purpose of this study was to screen and diagnose latent cases of autonomic neuropathy between patients who have a history of over 10 years DM and recently diagnosed diabetic patients. Methods: This cross-sectional study was performed on 104 patients (52 type 2 DM patients diagnosed in the last 6 months; and 52 type 2 DM patients with more than 10 years history) referred to outpatient Endocrine Clinic of Imam Reza Medical Center in Tabriz University of Medical Sciences between 2015-2016. Blood pressure, resting heart rate and corrected QT interval were evaluated according to standard methods. The history of gastrointestinal and urinary tract neuropathy was extracted from patients’ history and physical exam. Results: Of the 104 patients studied, 54 were male and 50 were female. Standing heart rate (p=0.02), resting (p<0.0002) and standing (p<0.0001) systolic blood pressure, and resting diastolic blood pressure (p=0.03) were significantly higher in chronic diabetic patients compared to newly diagnosed group. Additionally, blood glucose levels (p=0.03) and body mass index (BMI) (p<0.0001) were significantly higher in patients with neuropathy. Conclusion: Overall, the results of this study showed that in patients with type 2 DM, cardiac autonomic dysfunction is more common in patients with a longer history of DM.
No takes yet. Share an insight, caveat, or question.
Esmaeillou et al. (2020) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=104). Chronic type 2 diabetes (>10 years) vs. Newly diagnosed type 2 diabetes (<6 months) was evaluated on Cardiovascular autonomic impairment. Patients with a history of type 2 diabetes for over 10 years had a higher prevalence of cardiovascular autonomic impairment (30.76%) compared to newly diagnosed patients (7.69%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: