Key result
Autonomic dysfunction was present in 71.02% of patients with Type 2 diabetes, with no significant difference in prevalence between those with disease duration ≥5 years (68.2%) versus <5 years (75.8%).
Cross-Sectional (n=245)
Yes
Absolute Event Rate: 68.2% vs 75.8%
p-value: p=0.203
Autonomic dysfunction is highly prevalent (71%) in Type 2 diabetic patients regardless of disease duration, highlighting the need for early screening using simple cardiovascular reflex tests.
May support early autonomic screening in Type 2 diabetes; leaves open prospective validation of duration-independent risk.
Introduction: Dysfunction of the autonomic nervous system is common in diabetic patients. Presence of autonomic dysfunction should alert the physicians of its serious consequences that require timely preventive measures. Objectives: This study was done to fi nd out the autonomic nervous system involvement in Type 2 diabetic patients and to see its relation with the duration of diabetes. Methods: This was a hospital based cross-sectional study. All consecutive diabetic patients of both genders attending Kathmandu Medical College and a private clinic, Temple of Healing were included. A battery of six well validated and accepted autonomic nervous system evaluation tests were done to evaluate the autonomic function in 245 Type 2 diabetic patients. Results: Prevalence of autonomic dysfunction was found to be 71.02% with 58.78% patients having mild autonomic dysfunction and 12.24% having moderate dysfunction. Severe autonomic dysfunction was detected in none of the patients. Parasympathetic dysfunction was much more common than sympathetic dysfunction (68.16% vs. 17.96%). No association was found between autonomic dysfunction and duration of diabetes. Conclusions: Autonomic dysfunction is very common in diabetics and can be detected by simple tests. Timely detection of autonomic dysfunction in diabetic patients is advised so that its preventive measures can be effective. DOI: http://dx.doi.org/10.3126/jkmc.v1i2.8142 Journal of Kathmandu Medical College, Vol. 1, No. 2, Oct.-Dec., 2012: 77-83
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Karki et al. (2013) conducted a cross-sectional in Type 2 diabetes mellitus (n=245). Duration of diabetes ≥ 5 years vs. Duration of diabetes < 5 years was evaluated on Autonomic dysfunction (p=0.203). Autonomic dysfunction was present in 71.02% of patients with Type 2 diabetes, with no significant difference in prevalence between those with disease duration ≥5 years (68.2%) versus <5 years (75.8%).
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