Key result
Long duration of type 2 diabetes was associated with significantly worse cardiac autonomic function compared to recently diagnosed diabetes, including lower mean RR, SDNN, and HF nu (p < 0.001).
Why the study?
Does the duration of type 2 diabetes mellitus correlate with worsening cardiac autonomic dysfunction in male patients?
Cross-Sectional (n=84)
No
Does the duration of type 2 diabetes mellitus correlate with worsening cardiac autonomic dysfunction in male patients?
p-value: p=<0.001
Longer duration of type 2 diabetes mellitus is significantly associated with worse cardiac autonomic dysfunction as measured by heart rate variability.
Longer T2DM duration was associated with autonomic dysfunction; leaves open causality and need for prospective trials before clinical use.
Background: Duration of diabetes may have an important influence on cardiac autonomic dysfunction in type 2 diabetes mellitus.Objective: To assess the relationship of cardiac autonomic dysfunction in type 2 diabetes mellitus(T2DM) with the duration of diabetes.Methods: This crosssectional study was carried out from January to December 2015 on 54 long-term T2DM male patients aged 45 to 55 years, selected from the Endocrinology OPD of BSMMU, Dhaka. Thirty age matched recently diagnosed male T2DM patients(RT2DM) were control. Cardiac autonomic function was assessed by Heart Rate Variability(HRV). HRV measures were obtained by RMS multi channel polyrite-D. For statistical analysis, unpaired t-test and Pearsons correlation coefficient test were used.Results: Mean RR, SDNN, and HF nu were significantly lower (p < 0.001) whereas, mean HR, LF nu and LF/HF were significantly (p < 0.001) higher in LT2DM than those of RT2DM. SDNN, RMSSD and variance showed significant (p < 0.001) negative correlation with the duration of diabetes.Conclusions: Duration of diabetes had strong negative relationship with the diabetic cardiac autonomic dysfunction.Bangladesh Soc Physiol. 2016, June; 11(1): 1-5
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Phurpa et al. (2016) conducted a cross-sectional in Type 2 diabetes mellitus (n=84). Long duration of diabetes vs. Recently diagnosed diabetes was evaluated on Cardiac autonomic function assessed by Heart Rate Variability (HRV) (p=<0.001). Long duration of type 2 diabetes was associated with significantly worse cardiac autonomic function compared to recently diagnosed diabetes, including lower mean RR, SDNN, and HF nu (p < 0.001).
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