Key result
Individuals with T2DM showed impaired cardiac autonomic markers (mean RR 759 ms) and lower arterial stiffness (8.4 m/s) compared to those with SAH (962 ms; 10.3 m/s) and PD (976 ms; 10.6 m/s).
Why the study?
Systemic arterial hypertension, type 2 diabetes mellitus, and Parkinson's disease are prevalent chronic diseases affecting the cardiovascular system, but their resting hemodynamic and autonomic profiles had not been directly compared.
Cross-Sectional (n=50)
Individuals with T2DM exhibit more impaired cardiac autonomic markers compared to those with SAH or PD, despite having lower blood pressure and arterial stiffness.
T2DM-linked autonomic impairment and lower stiffness may mark distinct phenotypes; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson's disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system. AIM: The aim of this study was to compare hemodynamic and autonomic variables at rest in individuals with SAH, T2DM, or PD. METHODS: Fifty sedentary or insufficiently active individuals (22 men) with SAH (age = 66 ± 5.0 yr), T2DM (age = 52 ± 10 yr) or PD (age = 68 ± 8.0 yr) had their resting blood pressure (BP), arterial stiffness, endothelial function, and heart rate variability (HRV) assessed and compared. RESULTS: Systolic and diastolic BP were higher in SAH (130 ± 10 / 80 ± 10 mmHg) than T2DM (110 ± 14 / 75 ± 11 mmHg) and PD, and (123 ± 20 / 70 ± 11 mmHg) respectively. T2DM individuals showed lower arterial stiffness (8.4 ± 1.1 m/s), when compared to SAH (10.3 ± 2.3 m/s) and PD (10.6 ± 3.0 m/s). T2DM had greater resting tachycardia showed by the mean RR (759 ± 79 ms), than SAH (962 ± 169 ms) and PD (976 ± 134 ms), which was accompanied by higher sympathetic modulation (low frequency [LF]: 62 ± 19 nu) and lower parasympathetic modulation (high frequency [HF]: 32 ± 16 nu) when compared to SAH (LF: 40 ± 16 nu; HF: 61 ± 33 nu). No differences among groups were found on non-linear HRV markers and endothelial reactivity indexes. CONCLUSIONS: Individuals with T2DM showed impaired levels of cardiac autonomic markers when compared to individuals with SAH and PD, despite of having lower levels of BP and arterial stiffness.
No takes yet. Share an insight, caveat, or question.
Ngomane et al. (2021) conducted a cross-sectional in Systemic arterial hypertension, type 2 diabetes mellitus, and Parkinson's disease (n=50). Type 2 Diabetes Mellitus vs. Systemic arterial hypertension and Parkinson's disease was evaluated on Resting blood pressure, arterial stiffness, endothelial function, and heart rate variability. Individuals with T2DM showed impaired cardiac autonomic markers (mean RR 759 ms) and lower arterial stiffness (8.4 m/s) compared to those with SAH (962 ms; 10.3 m/s) and PD (976 ms; 10.6 m/s).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More on Hypertension managementMore from Clinical and Experimental Hypertension