Why the study?
Does sodium repletion affect hemodynamics and microcirculation differently in sodium-sensitive versus non-sensitive subjects?
Population
109 subjects (58 normal subjects and 51 subjects with borderline hypertension)
Comparison
Sodium depletion and repletion periods vs Ad libitum diet and comparison between…
Design
Cohort
Authors
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Supports microvascular mechanism in sodium-sensitive hypertension; hypothesis-generating and should not yet change practice.
Does sodium repletion affect hemodynamics and microcirculation differently in sodium-sensitive versus non-sensitive subjects?
Sodium sensitivity in humans is accompanied by elevated forearm vascular resistance and attenuated microcirculation, suggesting a microvascular mechanism for sodium-induced blood pressure increases.
Sullivan et al. (1987) studied this question.
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