Key result
Cigarette smoke exposure in rats decreased e-NOS levels and increased aortic IMT, with e-NOS levels negatively correlating with aortic IMT (β = -0.764, P<0.001).
Why the study?
Little was known about the role of cigarette smoking in the atherosclerotic inflammatory process, prompting exploration of its link with e-NOS and VCAM-1.
Does cigarette smoke exposure decrease e-NOS and increase VCAM-1 and aortic IMT in Wistar rats?
Population
18 Wistar rats (Rattus norvegicus)
Comparison
Tobacco smoke equivalent of >40 cigarettes daily vs no exposure
Design
Experimental post-test only controlled group design
Follow-up
28 days
Authors
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Animal findings link smoking to monocyte-driven atherosclerosis; hypothesis-generating for human endothelial dysfunction and IMT.
RCT (n=18)
Randomly subdivided
Does cigarette smoke exposure decrease e-NOS and increase VCAM-1 and aortic IMT in Wistar rats?
Effect estimate: β = -0.764
p-value: p=<0.001
Cigarette smoke exposure in a rat model decreases e-NOS and increases VCAM-1, which correlates with increased aortic intima-media thickness.
Ardiana et al. (2023) reported an RCT. Cigarette smoke exposure vs. Not exposed to tobacco smoke was evaluated on Correlation between e-NOS level and aortic IMT (β = -0.764, p=<0.001). Cigarette smoke exposure in rats decreased e-NOS levels and increased aortic IMT, with e-NOS levels negatively correlating with aortic IMT (β = -0.764, P<0.001).
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