Key result
Serum phosphorus (OR 2.569, p=0.01), CRP, lower albumin, and dialysis duration were independent risk factors for new-onset cardiac valve calcification in patients on maintenance peritoneal dialysis.
Cohort (n=194)
No
Odds Ratio: 2.569
p-value: p=0.01
In patients on maintenance peritoneal dialysis, higher serum phosphorus, CRP, longer dialysis duration, and lower albumin are independent risk factors for new-onset cardiac valve calcification.
Supports monitoring phosphorus and inflammation in peritoneal dialysis; leaves open causality and need for interventional trials.
OBJECTIVE: Patients with end-stage renal disease are susceptible to cardiac valve calcification (CVC) due to mineral metabolism disorders and other factors. The purpose of this study was to investigate the risk factors for new-onset CVC in patients on maintenance peritoneal dialysis (PD). METHODS: This study included patients who underwent PD catheter insertion from January 2006 to June 2013 in our Peritoneal Dialysis Center. Clinical data were collected on CVC status during echocardiography evaluations (twice) at an interval of >6 months. The data collected included intact parathyroid hormone, C-reactive protein (CRP), serum phosphorus (P), serum calcium (Ca), albumin (Alb), prealbumin and the use of five types of antihypertensive drugs, statins, active vitamin D3 and Ca tablets. RESULTS: In total, 194 patients - 105 (54.1%) men, average age 60.5 ± 13.0 years - were included. CVC was present in 50 (25.8%) patients during PD catheter placement. After an average PD duration of 20.9 ± 10.4 months, CVC was detected in 97 patients (50.0%). New-onset CVC was found in 62 patients (32.0%). Multivariate logistic regression analysis revealed that only serum P levels (p = 0.01, OR = 2.569), Alb levels (p = 0.04, OR = 0.935), dialysis duration (p = 0.03, OR = 1.039) and CRP levels (p = 0.02, OR = 1.031) were associated with CVC. CONCLUSION: Serum P, Alb and CRP levels as well as dialysis duration are independent risk factors for CVC.
No takes yet. Share an insight, caveat, or question.
Tian et al. (2016) conducted a cohort in Maintenance peritoneal dialysis (n=194). Serum phosphorus, albumin, CRP, and dialysis duration was evaluated on New-onset cardiac valve calcification (CVC) (OR 2.569, p=0.01). Serum phosphorus (OR 2.569, p=0.01), CRP, lower albumin, and dialysis duration were independent risk factors for new-onset cardiac valve calcification in patients on maintenance peritoneal dialysis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: