Key result
Valve calcification affects ~40% of hemodialysis patients and is linked to higher serum phosphorus.
Observational (n=90)
Absolute Event Rate: 69.7% vs 44.9%
p-value: p=<0.0001
In patients on maintenance hemodialysis, altered calcium and phosphate metabolism is significantly associated with the presence of heart valve calcification.
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Hyperphosphatemia linked to valve calcification in HD; hypothesis-generating, prospective trials needed before changing practice.
Tarrass et al. (2006) conducted an observational in End-stage renal disease on maintenance haemodialysis (n=90). Valve calcification vs. No valve calcification was evaluated on Serum phosphorus (mg/L) (p=<0.0001). Valve calcification was present in 40% of haemodialysis patients and was associated with significantly higher serum phosphorus (69.70 vs 44.90 mg/L, P<0.0001) and calcium-phosphorus product.
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