Key result
Increased pulse pressure linked to ~222% higher risk of cardiac valve calcification in ESKD.
Why the study?
Limited data are available concerning the prevalence, clinical features, and risk factors for cardiac valve calcification in end-stage kidney disease patients.
What are the risk factors for cardiac valve calcification in Chinese ESKD patients on combination hemodialysis and hemodiafiltration?
Cross-Sectional (n=293)
No
What are the risk factors for cardiac valve calcification in Chinese ESKD patients on combination hemodialysis and hemodiafiltration?
Odds Ratio: 3.22
p-value: p=<0.001
Diabetes, increased pulse pressure, long dialysis duration, hypoalbuminemia, and high serum calcium are independent risk factors for cardiac valve calcification in ESKD patients on hemodialysis and hemodiafiltration.
Identifies risk factor associations for valve calcification in ESKD; hypothesis-generating and requires prospective validation before practice change.
Background Cardiac valve calcification (CVC) is an important risk factor for cardiovascular complications. However, limited data are available concerning the prevalence, clinical features and risk factors for CVC in end-stage kidney disease (ESKD) patients. In this study, we aimed to assess these parameters in Chinese ESKD patients receiving combination therapy with hemodialysis and hemodiafiltration.Methods We conducted a cross-sectional study on 293 ESKD patients undergoing combination therapy of hemodialysis and hemodiafiltration at the First Affiliated Hospital of Chongqing Medical University from October 2014 to December 2015. CVC was evaluated via echocardiography.Results ESKD patients with CVC had a higher prevalence of diabetes mellitus, aortic and/or coronary artery calcification, arrhythmia, heart failure and coronary heart disease; increased systolic, diastolic and pulse pressure; longer duration of hemodialysis and hypertension; reduced hemoglobin, albumin and high-density lipoprotein cholesterol levels; and increased serum calcium and calcium-phosphorus product levels compared with those without CVC. Logistic regression analysis showed that increased dialysis duration (p = 0.006, OR = 2.25), serum calcium levels (p = 0.046, OR = 2.04) and pulse pressure (p < 0.001, OR = 3.22), the presence of diabetes (p = 0.037, OR = 1.81) and decreased serum albumin levels (p = 0.047, OR = 0.54) were risk factors for CVC. The correlation analysis indicated a significantly increased CVCs prevalence with an increase prevalence of heart failure, aortic and coronary artery calcification.Conclusions CVC represents a common complication and a danger signal for cardiovascular events in ESKD patients undergoing combination therapy of hemodialysis and hemodiafiltration. The presence of diabetes, increased pulse pressure, long dialysis duration, hypoalbuminemia and high serum calcium levels were independent risk factors for CVC.
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Jian-qiong et al. (2022) conducted a cross-sectional in End-stage kidney disease (ESKD) (n=293). Increased pulse pressure was evaluated on Cardiac valve calcification (CVC) (OR 3.22, p=<0.001). In ESKD patients, increased pulse pressure (OR 3.22), dialysis duration (OR 2.25), serum calcium (OR 2.04), and diabetes (OR 1.81) were independent risk factors for cardiac valve calcification.
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