What question did this study set out to answer?

To examine associations between self-reported consumption of total dairy, milk, cheese, and yogurt and the composition and diversity of the human colonic mucosa-associated microbiota.

February 2, 2025NutrientsOpen Access

Dairy Consumption and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation

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Authors

ECEllie ChenBaylor College of Medicine NANadim J. AjamiThe University of Texas MD Anderson Cancer Center DWDonna L. WhiteMichael E. DeBakey VA Medical Center

Discussion

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Implication

Cross-sectional study finds distinct colonic mucosa microbiota composition linked to dairy intake in polyp-free adults, indicating diet-driven modulation of gut bacteria.

Key Points

To examine associations between self-reported consumption of total dairy, milk, cheese, and yogurt and the composition and diversity of the human colonic mucosa-associated microbiota.
Analyzed 97 colonic mucosal biopsy samples obtained from 34 polyp-free individuals in a cross-sectional design.
Assessed past-year dairy intake using a food frequency questionnaire and profiled mucosal bacteria via 16S rRNA gene V4 region sequencing using UPARSE and SILVA databases.
Applied multivariable negative binomial regression models for panel data to estimate incidence rate ratios and 95% confidence intervals, evaluating statistical significance at false discovery rate q < 0.05.
Higher total dairy intake, higher milk intake, and lower cheese intake were significantly associated with increased alpha microbial diversity (adjusted p < 0.05).
Higher consumption of total dairy and milk was associated with higher relative abundance of Faecalibacterium, while higher milk intake specifically correlated with higher relative abundance of Akkermansia (q < 0.05).
Higher total dairy and cheese consumption was significantly associated with lower relative abundance of Bacteroides (q < 0.05).

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6a70737587f921057127afae https://doi.org/10.3390/nu17030567

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February 2, 2025NutrientsOpen Access

Dairy Consumption and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation

View Full Paper

Ask AI

Bookmark

Authors

ECEllie ChenBaylor College of Medicine NANadim J. AjamiThe University of Texas MD Anderson Cancer Center DWDonna L. WhiteMichael E. DeBakey VA Medical Center

Discussion

Member takes

Implication

Cross-sectional study finds distinct colonic mucosa microbiota composition linked to dairy intake in polyp-free adults, indicating diet-driven modulation of gut bacteria.

Key Points

To examine associations between self-reported consumption of total dairy, milk, cheese, and yogurt and the composition and diversity of the human colonic mucosa-associated microbiota.
Analyzed 97 colonic mucosal biopsy samples obtained from 34 polyp-free individuals in a cross-sectional design.
Assessed past-year dairy intake using a food frequency questionnaire and profiled mucosal bacteria via 16S rRNA gene V4 region sequencing using UPARSE and SILVA databases.
Applied multivariable negative binomial regression models for panel data to estimate incidence rate ratios and 95% confidence intervals, evaluating statistical significance at false discovery rate q < 0.05.
Higher total dairy intake, higher milk intake, and lower cheese intake were significantly associated with increased alpha microbial diversity (adjusted p < 0.05).
Higher consumption of total dairy and milk was associated with higher relative abundance of Faecalibacterium, while higher milk intake specifically correlated with higher relative abundance of Akkermansia (q < 0.05).
Higher total dairy and cheese consumption was significantly associated with lower relative abundance of Bacteroides (q < 0.05).

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6a70737587f921057127afae https://doi.org/10.3390/nu17030567

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