cAMP-dependent Protein Kinase Induces cAMP-response Element-binding Protein Phosphorylation via an Intracellular Calcium Release/ERK-dependent Pathway in Striatal Neurons

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Population

Striatal primary cultures (striatal neurons)

Design

Preclinical

Authors

Discussion

Highlights Rap1-ERK-calcium signaling in striatal CREB activation; leaves open translation to human disease models.

Population

Striatal primary cultures (striatal neurons)

Intervention

Activation of the cAMP/PKA-dependent pathway

Outcome

CREB phosphorylation and CREB-dependent transcriptionsurrogate

In striatal neurons, intracellular calcium release, Rap1, and the ERK pathway play a crucial role in PKA-induced CREB phosphorylation.

Zanassi et al. (2001) studied this question.

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