Key result
Non-coding RNAs, primarily microRNAs, contribute to the normal configuration of the cardiac action potential and are associated with distinct types of arrhythmogenic cardiac diseases.
Why the study?
Cardiac arrhythmias share complex cellular electrophysiologic properties that have not been fully studied, while understanding of non-coding RNA functional roles has progressively grown.
This review highlights the emerging understanding of how non-coding RNAs, particularly microRNAs, regulate the cardiac action potential and contribute to arrhythmogenic diseases.
Cardiac arrhythmias are prevalent among humans across all age ranges, affecting millions of people worldwide. While cardiac arrhythmias vary widely in their clinical presentation, they possess shared complex electrophysiologic properties at cellular level that have not been fully studied. Over the last decade, our current understanding of the functional roles of non-coding RNAs have progressively increased. microRNAs represent the most studied type of small ncRNAs and it has been demonstrated that miRNAs play essential roles in multiple biological contexts, including normal development and diseases. In this review, we provide a comprehensive analysis of the functional contribution of non-coding RNAs, primarily microRNAs, to the normal configuration of the cardiac action potential, as well as their association to distinct types of arrhythmogenic cardiac diseases.
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Lozano-Velasco et al. (2021) conducted a review in Cardiac arrhythmias. Non-coding RNAs (microRNAs) was evaluated. Non-coding RNAs, primarily microRNAs, contribute to the normal configuration of the cardiac action potential and are associated with distinct types of arrhythmogenic cardiac diseases.
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