Key result
Non-coding RNAs and gut microbiota might be involved in the pathogenesis of cardiac arrhythmias by regulating gene expression in cardiomyocytes and the immune system.
Why the study?
Although ncRNAs are linked to cardiac arrhythmias, it remains largely unclear how they regulate cardiac conduction and remodeling molecules, including potential interactions with gut microbiota and the immune system.
This review highlights the potential role of non-coding RNAs and gut microbiota in the pathogenesis of cardiac arrhythmias, suggesting new avenues for innovative therapies.
ncRNA-arrhythmia associations remain hypothesis-generating; leaves open their role as biomarkers or targets pending validation.
The non-coding RNAs (ncRNAs) are indispensable for controlling genes and genetic programming during development, as well as for health and cardiovascular diseases. Cardiac arrhythmia is a frequent cardiovascular disease, which has a complex pathology. Recent studies have shown that ncRNAs are also associated with cardiac arrhythmias. Many non-coding RNAs and/or genomes have been reported as a genetic background for cardiac arrhythmias. Arrhythmias may be affected by several functional and structural changes in the myocardium. Therefore, ncRNAs might be indispensable regulators of gene expression in cardiomyocytes, which could play a dynamic role in regulating the stability of cardiac conduction and/or in the remodeling process. Although it remains almost unclear how ncRNAs regulate the expression of molecules for controlling the cardiac conduction and/or in the remodeling process, gut microbiota and immune system within the intricate networks might be involved in the regulatory mechanisms. This study would discuss them and provide a research basis for ncRNAs modulation, which might support the development of emerging innovative therapies against cardiac arrhythmias.
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Suga et al. (2023) conducted a review in Cardiac arrhythmias. Non-coding RNAs and gut microbiota was evaluated. Non-coding RNAs and gut microbiota might be involved in the pathogenesis of cardiac arrhythmias by regulating gene expression in cardiomyocytes and the immune system.
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