Key result
Non-coding RNAs are involved in the pathophysiology of arrhythmias, particularly atrial fibrillation, and may serve as novel mechanistic-based therapeutic targets.
Why the study?
Current antiarrhythmic therapies lack sufficient efficacy and have potential adverse effects due to limited understanding of pathological mechanisms, highlighting the need to explore non-coding RNAs as mechanisms and therapeutic targets.
This review highlights the emerging role of non-coding RNAs in the pathophysiology of arrhythmias, particularly atrial fibrillation, suggesting their potential as novel therapeutic targets.
Answers are grounded in this paper and cite their sources.
May inform arrhythmia research on non-coding RNAs; leaves open clinical translation pending validation trials.
Arrhythmias are a class of cardiac dysfunction characterized by heart rate disturbances and heart rhythm abnormalities, which are associated with substantial morbidity and mortality. Due to the limited understanding of pathological mechanism, current antiarrhythmic drugs and invasive therapies on arrhythmias lack sufficient efficacy and are always accompanied by potential adverse effects. Non-coding RNAs (including microRNAs, long non-coding RNAs, circular RNAs, and other small non-coding RNAs) have been demonstrated to be involved in the occurrence and development of various diseases including arrhythmias, which opens a new prospect for exploring the mechanism of arrhythmias and developing new therapeutic targets. Therefore, in this review, we aimed to provide an overview of the expression of ncRNAs in various arrhythmias, their roles in the arrhythmia's development and pathophysiology, and the potential mechanism of ncRNAs in arrhythmias. As atrial fibrillation (AF) is the most common arrhythmia in clinical practice and current studies mainly focus on it, this review primarily discussed about AF. It was expected that this review may provide a basis for a better understanding of the mechanistic role of ncRNAs in arrhythmias and facilitate the development of mechanic-based therapeutic targets.
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Zeng et al. (2023) conducted a review in Arrhythmias (Atrial Fibrillation). Non-coding RNAs was evaluated. Non-coding RNAs are involved in the pathophysiology of arrhythmias, particularly atrial fibrillation, and may serve as novel mechanistic-based therapeutic targets.
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