Key result
The TDPscreen algorithm, based on isolated canine Purkinje fibre electrophysiological patterns, enabled clear separation of 45 reference compounds into three groups according to clinical TdP risk.
Population
Isolated canine Purkinje fibres
Design
Preclinical
Authors
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Supports preclinical TdP risk categorization; leaves open human translation and prospective validation.
An algorithm based on isolated canine Purkinje fibre electrophysiology can accurately categorize drugs by their clinical risk of Torsade de Pointes, offering a tool for early preclinical screening.
Champéroux et al. (2005) studied Torsade de Pointes (n=45). TDPscreen algorithm was evaluated on Separation of drugs into risk groups. The TDPscreen algorithm, based on isolated canine Purkinje fibre electrophysiological patterns, enabled clear separation of 45 reference compounds into three groups according to clinical TdP risk.
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