Key result
High-dose steroids plus immunosuppression achieve clinical improvement and discharge in SRP-IMNM with myocardial involvement.
Case Report (n=1)
Highlights the successful management of a rare case of SRP-IMNM with myocardial involvement presenting as decompensated heart failure using high-dose corticosteroids and immunosuppression.
A 62-year-old female was referred to the acute medical unit with a history of progressively worsening mobility, shortness of breath and leg swelling over the last few months. Initial investigations revealed hypoxia with features of decompensated heart failure (HF) and a significantly elevated troponin. The patient developed a rapidly progressive type two respiratory failure (T2RF) over 24 hours requiring non-invasive ventilation (NIV). There was evidence of marked proximal and respiratory muscle weakness and following investigation the patient was diagnosed with anti-signal-recognition-particle immune mediated necrotising myopathy (SRP-IMNM) with myocardial and respiratory involvement. Following the introduction of high dose corticosteroid and further immunosuppression, the patient was discharged well and has had persistent improvement over the subsequent year.
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Rashed et al. (2025) conducted a case report in anti-signal-recognition-particle immune mediated necrotising myopathy (SRP-IMNM) with myocardial and respiratory involvement (n=1). High dose corticosteroid and further immunosuppression was evaluated on Clinical improvement and discharge. Treatment with high dose corticosteroids and immunosuppression led to persistent clinical improvement and successful discharge in a 62-year-old female with SRP-IMNM and myocardial involvement.
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