Population
Seven SERCA2a mutants with amino acid substitutions at Ca-binding site I, site II, or both sites
Comparison
Micromolar Ca(2+) vs Absence of Ca(2+)
Design
Preclinical
Authors
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Provides mechanistic basis for SERCA2a-targeted heart failure therapies; hypothesis-generating in animal models pending human validation.
Ca2+ binding to site I of SERCA2a is the key event required for the dissociation of its inhibitor phospholamban, providing mechanistic insight into cardiac calcium cycling.
Chen et al. (2009) studied this question.
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