Population
Cardiac sarcoplasmic reticulum Ca2+ pump (SERCA2a) and phospholamban (PLB) mutants
Comparison
Loss-of-function mutations at Leucine 31 of PLB… vs Wild-type SERCA2a and PLB
Design
Preclinical
Authors
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Highlights PLB-SERCA2a interaction mechanisms; extends molecular insights but leaves open therapeutic translation in heart failure.
Leucine 31 of phospholamban is essential for productive inhibitory interaction with SERCA2a, though loss-of-function mutants at this position still retain binding capability.
Chen et al. (2005) studied this question.
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