What question did this study set out to answer?

To evaluate the development and six-month persistence of mucosal and systemic isotype-specific hemagglutinin antibody responses following live attenuated or inactivated influenza A vaccination.

January 1, 1986Journal of Clinical MicrobiologyOpen Access

Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine

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To evaluate the development and six-month persistence of mucosal and systemic isotype-specific hemagglutinin antibody responses following live attenuated or inactivated influenza A vaccination.
Administered intranasal live attenuated cold-adapted virus (H3N2 or H1N1) or subcutaneous licensed subvirion inactivated vaccine to 109 seronegative adults (hemagglutination-inhibiting titer ≤1:8).
Measured nasal-wash and serum isotype-specific hemagglutinin IgA and IgG responses via enzyme-linked immunosorbent assay over a follow-up period of at least 6 months.
Inactivated virus induced higher serum antibody titers and higher response rates than live virus for serum IgA (96% vs. 83%), serum IgG (100% vs. 72%), and nasal-wash IgG (94% vs. 59%, P < 0.01).
Live attenuated virus stimulated local nasal IgA antibody responses in 83% of recipients compared with only 38% in recipients of inactivated vaccine.
Serum IgA, serum IgG, and nasal IgG levels persisted above prevaccination levels for at least 6 months in most responders, though local nasal IgA induced by live virus declined substantially.

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Implication

Comparative trial reveals divergent mucosal and systemic antibody responses to live versus inactivated influenza vaccines in adults, indicating live formulations are viable alternatives.

Cite This Study

Clements et al. (1986) studied this question.

synapsesocial.com/papers/6a707b7c26a7f98052dcfa99 https://doi.org/10.1128/jcm.23.1.66-72.1986

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Implication

Comparative trial reveals divergent mucosal and systemic antibody responses to live versus inactivated influenza vaccines in adults, indicating live formulations are viable alternatives.

Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine

Key Points

Discussion

Implication

Cite This Study

Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine

Key Points

Discussion

Implication

Cite This Study

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