What question did this study set out to answer?

The aim is to compare immune responses and infection rates between young and elderly adults after vaccination with a live attenuated influenza virus.

February 1, 1992Journal of the American Geriatrics Society

Reduced Infectivity of Cold‐Adapted Influenza A H1N1 Viruses in the Elderly: Correlation with Serum and Local Antibodies

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Authors

DPDouglas C. PowersUniversity of Cambridge BMBrian R. Murphy LFLouis FriesNovavax (United States)

Discussion

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Implication

Retrospective analysis compares immune responses in young and elderly adults following intranasal vaccination, suggesting age-related differences in effectiveness.

Key Points

The aim is to compare immune responses and infection rates between young and elderly adults after vaccination with a live attenuated influenza virus.
Time series analysis comparing young and elderly adults using convenience samples.
Retrospective analysis of serum and nasal wash specimens from vaccinated individuals.
Measured antibody responses in serum and nasal washes post-vaccination.
20 out of 20 young vaccinees developed an antibody response, compared to 5 out of 14 elderly subjects (P<0.0005).
Resistance to the cold-adapted virus was correlated with pre-vaccination IgG, IgA levels, and nasal wash IgA antibodies.
Age was correlated with lower vaccine response, though this was adjusted for pre-existing antibody levels.

Cite This Study

Powers et al. (1992) studied this question.

synapsesocial.com/papers/6a216b424f27a676ef8b6b5f https://doi.org/10.1111/j.1532-5415.1992.tb01938.x

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Implication

Retrospective analysis compares immune responses in young and elderly adults following intranasal vaccination, suggesting age-related differences in effectiveness.

Reduced Infectivity of Cold‐Adapted Influenza A H1N1 Viruses in the Elderly: Correlation with Serum and Local Antibodies

Discussion

Member takes

Implication

Key Points

Cite This Study

Reduced Infectivity of Cold‐Adapted Influenza A H1N1 Viruses in the Elderly: Correlation with Serum and Local Antibodies

Discussion

Member takes

Implication

Key Points

Cite This Study

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