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This research aims to examine the effects of aging on immune responses to influenza vaccines in different age groups.

November 25, 2025The Journal of ImmunologyOpen Access

The impact of aging on adaptive immune responses to improved licensed influenza vaccines 4708

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Cohort study shows poor CD4+ T cell responses post-vaccination in older adults, indicating the need for improved vaccines.

This research aims to examine the effects of aging on immune responses to influenza vaccines in different age groups.
Cohort study involving 15 older adults (over 65 years) and 32 younger adults (under 45 years).
Assessment of vaccine-elicited B and CD4+ T cell responses at days 7 and 28 post-vaccination.
Immune profiling of T follicular helper cells and memory CD4+ T cells in both age groups.
Both age groups mounted similar antibody responses by day 28 post-vaccination.
Younger adults showed higher frequencies of H1N1 and H3N2 reactive memory CD4+ T cells by day 7 post-vaccination.
Older adults had reduced antiviral gene profiles related to activated T cells after stimulation with inactivated virus.

Oakes et al. (2025) studied this question.

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