What question did this study set out to answer?

This study aims to investigate how immunosuppressive cell populations affect immune responses to influenza vaccination across different age groups.

August 9, 2026VaccinesOpen Access

Association Between Immunosuppressive Cell Populations and Immune Response to Influenza Vaccination in Younger and Older Adults

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Randomized trial evaluates immune response to influenza vaccination in younger and older adults, suggesting implications for vaccination efficacy.

This study aims to investigate how immunosuppressive cell populations affect immune responses to influenza vaccination across different age groups.
Evaluated immune responses to the 2019/2020 quadrivalent influenza vaccine in 75 individuals aged 25–89 years.
Measured influenza-specific antibody titers and virus-neutralizing activity before and four weeks after vaccination.
Stratified participants into high or low responders based on their immune responses.
Older individuals showed higher frequencies of myeloid-derived suppressor cells (MDSCs) and activated regulatory T (Treg) cells, indicating greater immunosuppressive activity.
Higher levels of these immunoregulatory populations correlated with poorer vaccine responsiveness in older participants and low responders.
Most immunoregulatory subsets, except CD38+ Treg cells, were not independently associated with responder status after adjusting for confounders.

Placido et al. (2026) studied this question.

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Randomized trial evaluates immune response to influenza vaccination in younger and older adults, suggesting implications for vaccination efficacy.