What question did this study set out to answer?

The aim is to understand the immune mechanisms behind varied responses to the influenza vaccine in older adults, particularly focusing on B cells and cTfh activation.

July 30, 2026The Journal of Immunology

Impaired B Cell and cTfh Immune Pathways Underlie Influenza Vaccine Hyporesponsiveness in Older, Frail, and Multimorbid Adults 2309992

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Authors

JKJoseph KassBaylor College of Medicine BTBanumathi TamilselvanCase Western Reserve University BRBrian RichardsonUniversity School

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Implication

Randomized trial identifies immune pathway differences impacting flu vaccine responsiveness in older adults, suggesting improvements for frail populations.

Key Points

The aim is to understand the immune mechanisms behind varied responses to the influenza vaccine in older adults, particularly focusing on B cells and cTfh activation.
Samples collected from 21 frail nursing home residents receiving the flu vaccine were analyzed.
Hemagglutinin inhibition assays quantified antibody responses to classify individuals as HyperR or HypoR.
RNA-seq transcriptional analysis was performed post-stimulation on purified cTfh and B-cell samples.
HyperR showed increased expression of genes involved in antigen presentation, germinal-center differentiation, and metabolic activation.
AICDA, a key enzyme for somatic hypermutation, was significantly higher in HyperR, while other survival and differentiation genes were also elevated.
HypoR demonstrated less pathway activity and higher expression of the checkpoint receptor TIGIT, indicating impaired immune response.

Cite This Study

Kass et al. (2026) studied this question.

synapsesocial.com/papers/6a6af56d60e2b924d3ea1a45 https://doi.org/10.1093/jimmun/vkag141.1663

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Implication

Randomized trial identifies immune pathway differences impacting flu vaccine responsiveness in older adults, suggesting improvements for frail populations.

Impaired B Cell and cTfh Immune Pathways Underlie Influenza Vaccine Hyporesponsiveness in Older, Frail, and Multimorbid Adults 2309992

Discussion

Member takes

Implication

Key Points

Cite This Study

Impaired B Cell and cTfh Immune Pathways Underlie Influenza Vaccine Hyporesponsiveness in Older, Frail, and Multimorbid Adults 2309992

Discussion

Member takes

Implication

Key Points

Cite This Study

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