Key result
Post-CPB hypotension (MAP < 55 mmHg) was associated with increased odds of in-hospital mortality in intermediate-risk patients (adjusted OR 1.30; 95% CI 1.13-1.49; p=0.002 per 10 min exposure).
Why the study?
Intraoperative hypotension is a known mortality risk factor after noncardiac surgery, but remains relatively unexplored in cardiac surgery.
Does intraoperative hypotension increase in-hospital mortality in adult patients undergoing cardiac surgery requiring cardiopulmonary bypass?
Population
6627 consecutive adult cardiac surgery patients requiring cardiopulmonary bypass
Comparison
Intraoperative hypotension (MAP <55 and 55–64 mmHg) before, during, and after CPB across CARE risk groups
Design
Retrospective cohort study
Follow-up
In-hospital
Authors
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May warrant post-CPB MAP vigilance in intermediate-risk patients; hypothesis-generating for trials on targeted interventions.
Cohort (n=6,627)
Does intraoperative hypotension increase in-hospital mortality in adult patients undergoing cardiac surgery requiring cardiopulmonary bypass?
Odds Ratio: 1.3 (95% CI 1.13–1.49)
p-value: p=0.002
Post-cardiopulmonary bypass hypotension is a potentially modifiable risk factor associated with increased in-hospital mortality in intermediate-risk cardiac surgery patients.
Ristovic et al. (2020) conducted a cohort in Cardiac surgery requiring cardiopulmonary bypass (n=6,627). Intraoperative hypotension (MAP < 65 mmHg) vs. No hypotension was evaluated on In-hospital mortality (adjusted OR 1.30, 95% CI 1.13-1.49, p=0.002). Post-CPB hypotension (MAP < 55 mmHg) was associated with increased odds of in-hospital mortality in intermediate-risk patients (adjusted OR 1.30; 95% CI 1.13-1.49; p=0.002 per 10 min exposure).
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