What question did this study set out to answer?

This research aims to explore the role of nitric oxide in regulating sympathetic nerve activity within the rostral ventrolateral medulla.

April 1, 1995AJP Regulatory Integrative and Comparative Physiology

Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide

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Population

Chloralose-anesthetized cats, completely baro- and chemoreceptor denervated

Comparison

Microinjections of NG-nitro-L-arginine, an… vs NG-nitro-D-arginine

Design

Preclinical

Authors

JZJohannes ZanzingerPfizer (United States)JCJ. CzachurskiHeidelberg University HSH. SellerHeidelberg University

Discussion

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Implication

No immediate clinical implications; leaves open whether RVLM nitric oxide modulation affects human sympathetic control.

Key Points

This research aims to explore the role of nitric oxide in regulating sympathetic nerve activity within the rostral ventrolateral medulla.
Chloralose-anesthetized cats were baro- and chemoreceptor denervated.
Microinjections were performed in the RVLM and sympathetic nerve activity recorded.
Responses to electrical stimulation and baroreflex activation were measured and analyzed.
Inhibition of nitric oxide synthase by L-NNA caused significant increases in sympathetic nerve activity and arterial blood pressure.
Excitatory reflex responses from stimulation of intercostal nerves were intensified by L-NNA, while baroreflex responses remained unchanged.
NO-donors glyceryltrinitrate and S-nitroso-N-acetylpenicillamine decreased blood pressure and sympathetic nerve activity below control values.

Structured PICO

Population

Chloralose-anesthetized cats, completely baro- and chemoreceptor denervated

Intervention

Microinjections of NG-nitro-L-arginine (L-NNA), an inhibitor of NO synthase, into the rostral ventrolateral medulla (RVLM)

Comparator

NG-nitro-D-arginine

Outcome

Sympathetic nerve activity (SNA) and arterial blood pressure (BP)surrogate

Endogenous nitric oxide in the rostral ventrolateral medulla modulates central cardiovascular control by reducing basal sympathetic tone and attenuating excitatory reflex responses.

Cite This Study

Zanzinger et al. (1995) studied this question.

synapsesocial.com/papers/6a707e2da7fbea1e44081962 https://doi.org/10.1152/ajpregu.1995.268.4.r958

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Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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