March 8, 2005HypertensionOpen Access

Selective Sensitization by Nitric Oxide of Sympathetic Baroreflex in Rostral Ventrolateral Medulla of Conscious Rabbits

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Population

Conscious rabbits

Comparison

Microinjections of NO donors, NO, NOS… vs Inactive enantiomer D-NAME or baseline conditions

Design

Preclinical

Authors

DMDmitry N. MayorovThe University of Melbourne

Discussion

Member takes

Implication

Neuronal NOS may facilitate sympathetic baroreflex gain in rabbits; leaves open relevance to human hypertension management.

Structured PICO

Population

Conscious rabbits

Intervention

Microinjections of NO donors (S-nitroso-N-acetylpenicillamine, sodium nitroprusside), NO, NOS inhibitors (L-NAME, 7-nitroindazole, S-methylisothiourea, aminoguanidine), and sGC inhibitors (ODQ, methylene blue) into the rostral ventrolateral medulla (RVLM)

Comparator

Inactive enantiomer D-NAME or baseline conditions

Outcome

Resting blood pressure, heart rate, renal sympathetic nerve activity (RSNA), and RSNA baroreflex gainsurrogate

Neuronal NOS-derived NO facilitates sympathetic baroreflex transmission in the RVLM via a sGC-dependent mechanism, but local nNOS and iNOS play little role in tonic blood pressure support in conscious rabbits.

Cite This Study

Dmitry N. Mayorov (2005) studied this question.

synapsesocial.com/papers/6a82a9c25bcab2ccdb8d6546 https://doi.org/10.1161/01.hyp.0000160322.83725.6b

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Bookmark

Selective Sensitization by Nitric Oxide of Sympathetic Baroreflex in Rostral Ventrolateral Medulla of Conscious Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Selective Sensitization by Nitric Oxide of Sympathetic Baroreflex in Rostral Ventrolateral Medulla of Conscious Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider