March 1, 2013BMC BioinformaticsOpen Access

Bioinformatics analysis of the epitope regions for norovirus capsid protein

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Population

18 full-length human norovirus capsid protein sequences (7 GI and 11 GII) downloaded from GenBank/NCBI

Design

Preclinical

Authors

LCLiping ChenChongqing University of Technology DWDi WuJingdezhen Ceramic Institute LJLei JiXuzhou Medical College

Discussion

Member takes

Implication

May inform norovirus vaccine design; leaves open immunogenicity and protective efficacy in vivo.

Structured PICO

Population

18 full-length human norovirus capsid protein sequences (7 GI and 11 GII) downloaded from GenBank/NCBI

Intervention

Protein 3D structure modeling and conformational epitope prediction using SEPPA

Outcome

Predicted conformational epitope regions

Computational modeling of norovirus capsid proteins identified common and exclusive conformational epitopes, which may guide future vaccine and monoclonal antibody design.

Cite This Study

Chen et al. (2013) studied this question.

synapsesocial.com/papers/6a707f59ac440176ef29288f https://doi.org/10.1186/1471-2105-14-s4-s5

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Bioinformatics analysis of the epitope regions for norovirus capsid protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bioinformatics analysis of the epitope regions for norovirus capsid protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider