This review provides an overview of different methods used to induce myocardial infarction in experimental animals, highlighting their respective advantages and disadvantages.
Animal models aid MI pathophysiology research despite imperfect human mimicry; leaves open optimal model selection for translational studies.
Myocardial Infarction (MI) is a major health problem worldwide. Animal models have been used extensively in scientific research. This was intended to help researchers to understand the underlying pathophysiology of MI, compensatory mechanisms involved and efficacy of treatment. Although, it is difficult to create necrosis similar to those found in human heart, various large and small animals were used to create experimental model of MI. Each of these animals and method of selection offers various advantages and disadvantages in relation to clinical studies. In the present review, we aim to highlight the different methods used to induce MI in experimental animals. These methods may be beneficial for academicians and researchers concerned with the treatment of MI.
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Halim et al. (2018) studied this question.
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