Population
Mice (ventricle tissue and isolated cardiac myocytes)
Comparison
Verapamil, isoproterenol, or isoproterenol +… vs Control
Design
Preclinical
Follow-up
24 to 48 hours
Authors
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Should not alter verapamil use in patients; extends compensatory upregulation hypothesis in rodent models.
Long-term calcium channel blockade with verapamil induces a compensatory increase in Ca(V)1.2 expression and L-type calcium current in mouse ventricles.
Schroder et al. (2006) studied this question.
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