Why the study?
Does amlodipine maintain blood pressure control better than diltiazem during short interruptions of therapy in hypertensive patients?
Population
34 hypertensive patients
Comparison
Amlodipine 5 mg once daily for 9-10 weeks, with… vs Diltiazem 90 mg twice daily for 9-10 weeks, with…
Design
RCT, randomized, double-blind
Follow-up
9-10 weeks
Authors
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Supports amlodipine over diltiazem for patients with imperfect adherence; extends RCT evidence on CCB duration to short therapy interruptions.
Does amlodipine maintain blood pressure control better than diltiazem during short interruptions of therapy in hypertensive patients?
Amlodipine maintains blood pressure control better than diltiazem during short periods of noncompliance due to its longer elimination half-life.
Leenen et al. (1996) studied this question.
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