Key result
Omitting amlodipine for three days causes no significant BP increase versus continuous therapy.
Why the study?
The duration of the antihypertensive effect of amlodipine after treatment discontinuation in well-controlled mild to moderate hypertensive patients was unclear.
Does a 3-day discontinuation of amlodipine 5 mg once daily increase blood pressure compared to continuous therapy in well-controlled mild to moderate hypertensive patients?
Population
Mild to moderate hypertensive patients previously well-controlled on amlodipine 5 mg once daily for 6 weeks
Comparison
Amlodipine 5 mg once daily continuously vs amlodipine 5 mg once daily for 12 days followed by 3-day placebo
Design
Prospective double-blind randomized study
Follow-up
3 days after discontinuing therapy
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Supports short-term amlodipine omission in stable hypertension; confirms prolonged duration of action in RCT data.
RCT
Double-blind
Does a 3-day discontinuation of amlodipine 5 mg once daily increase blood pressure compared to continuous therapy in well-controlled mild to moderate hypertensive patients?
Amlodipine maintains its antihypertensive effect even after a 3-day treatment omission, demonstrating a prolonged duration of action.
A 1999 study conducted an RCT in Mild to moderate hypertension. Amlodipine omission (placebo) vs. Continuous amlodipine 5 mg O.D. was evaluated on Blood pressure (BP) evaluated by conventional (OBP) and ambulatory blood pressure monitoring (ABPM). Omitting amlodipine 5 mg daily for 3 days resulted in no significant increase in blood pressure compared to continuous therapy.
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