Why the study?
Previous studies suggested obesity blunts postprandial metabolic flexibility, motivating direct analysis of the effect of body composition on postprandial metabolic flexibility.
Healthy young adults with higher body fat percentages maintain a preserved, metabolically flexible phenotype, challenging the notion that increased adiposity universally blunts metabolic flexibility in this demographic.
Challenges prior assumptions of blunted flexibility in obesity; leaves open effects in older or clinical populations.
Previous studies have suggested that obesity blunts postprandial metabolic flexibility. By directly analyzing the effect of body composition on postprandial metabolic flexibility, we show that healthy young adults with higher body fat percentages have increased postprandial metabolic flexibility in response to concurrent hyperglycemia. This suggests a preserved, metabolically flexible phenotype in young adults with higher body fat percentages.
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Foreman et al. (2025) studied this question.
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