What question did this study set out to answer?

To examine fat oxidation and hormonal responses to a high-fat meal in formerly obese women with a family history of obesity compared with matched controls.

October 1, 1994AJP Endocrinology and Metabolism

Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity

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Authors

ARAnne RabenUniversity of Copenhagen HAHenning Boje AndersenTokyo Institute of Technology NCN. J. ChristensenStatens Serum Institut

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Implication

Controlled study reveals suppressed fat oxidation and altered hormonal responses after high-fat meals in postobese women, indicating a biological predisposition toward enhanced lipid storage.

Key Points

To examine fat oxidation and hormonal responses to a high-fat meal in formerly obese women with a family history of obesity compared with matched controls.
Conducted a controlled trial comparing 12 normal-weight postobese women (familial obesity history) with 12 closely matched controls.
Preconditioned participants with a 2-day carbohydrate-rich weight-maintenance diet (58 E% carbohydrate) before administering a high-fat test meal (50 E% fat).
Assessed postprandial thermic effects, substrate oxidation, arterialized plasma nonesterified fatty acids, triglycerides, and metabolic hormone levels.
Postprandial fat oxidation was 2.5 times more suppressed in postobese women compared to controls (P < 0.05), alongside a similarly enhanced suppression of plasma nonesterified fatty acids (P < 0.05).
Postprandial plasma triglyceride response was significantly lower in postobese subjects, reaching only 43% of the response observed in controls (P < 0.05).
Postobese women demonstrated a greater increase in gastric inhibitory polypeptide, a reduced glucagon response, and more marked epinephrine suppression, with no differences in overall meal thermic effect or appetite.

Cite This Study

Raben et al. (1994) studied this question.

synapsesocial.com/papers/6a705a20fe4101aa97e0205c https://doi.org/10.1152/ajpendo.1994.267.4.e549

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Implication

Controlled study reveals suppressed fat oxidation and altered hormonal responses after high-fat meals in postobese women, indicating a biological predisposition toward enhanced lipid storage.

Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

Evidence for an abnormal postprandial response to a high-fat meal in women predisposed to obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

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