What does this research mean for the field?

Postprandial leptin concentrations progressively decline following a high-fat meal, whereas adiponectin levels remain unaffected by meal composition, demonstrating that adipokine dynamics are influenced by food intake, sex, and BMI. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

The aim is to assess how meal composition affects postprandial leptin and adiponectin responses in adults with varying obesity statuses.

May 20, 2026PLoS ONEOpen Access

Postprandial response of leptin and adiponectin to standardized high-carbohydrate and high-fat meals in adults: A cross-sectional study

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Authors

FRFabiola Mabel Del Razo-OlveraUniversidad La Salle AAAna T. Arias-MarroquínInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán MMMayra Martínez-FajardoUniversidad La Salle

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Implication

Cross-sectional study evaluates leptin and adiponectin responses to high-carb and high-fat meals in adults, indicating meal type affects metabolic health.

Key Points

The aim is to assess how meal composition affects postprandial leptin and adiponectin responses in adults with varying obesity statuses.
Analyzed postprandial responses of leptin and adiponectin in 79 adults (43 women, 36 men; 47% with obesity).
Conducted two mixed-meal tolerance tests: one high in carbohydrates and one high in fat.
Blood samples were taken at baseline and at 60, 120, and 360 minutes, analyzed using linear mixed-effects models.
Higher leptin and adiponectin were observed in women compared to men (p < 0.001).
Adults with obesity showed higher leptin but lower adiponectin levels across all time points (p < 0.001).
Meal type significantly influenced leptin trajectories, declining after the high-fat meal but not changing significantly after the high-carbohydrate meal.

Cite This Study

Razo-Olvera et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5089f03e14405aa9c670 https://doi.org/10.1371/journal.pone.0349380

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Implication

Cross-sectional study evaluates leptin and adiponectin responses to high-carb and high-fat meals in adults, indicating meal type affects metabolic health.

Postprandial response of leptin and adiponectin to standardized high-carbohydrate and high-fat meals in adults: A cross-sectional study

Discussion

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Implication

Key Points

Cite This Study

Postprandial response of leptin and adiponectin to standardized high-carbohydrate and high-fat meals in adults: A cross-sectional study

Discussion

Member takes

Implication

Key Points

Cite This Study

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