Key result
A fixed breakfast induced a 4-fold increase in plasma adiponectin at 60 minutes in obese subjects (from 2.9 to 12.1 microg/mL; p<0.0001), with no postprandial changes in lean subjects.
Why the study?
Does a fixed breakfast alter plasma adiponectin concentrations differently in obese versus lean subjects?
Observational (n=24)
Does a fixed breakfast alter plasma adiponectin concentrations differently in obese versus lean subjects?
Absolute Event Rate: 12.1% vs 2.9%
p-value: p=<0.0001
Plasma adiponectin increases significantly postprandially in obese but not lean subjects, potentially serving as a compensatory mechanism for maintaining glucose tolerance.
May not alter breakfast advice yet; hypothesis-generating for compensatory adiponectin responses in obesity.
OBJECTIVE: We investigated the acute responses of plasma adiponectin levels to a test meal in lean and obese subjects. RESEARCH METHODS AND PROCEDURES: We studied 13 lean and 11 obese subjects after a 10-hour overnight fast. Glucose, insulin, and adiponectin concentrations were measured at baseline and 15, 30, 60, 120, and 180 minutes after a fixed breakfast. RESULTS: At baseline, fasting adiponectin concentrations were lower in the obese group vs. the lean group [mean (95% confidence interval): 2.9 (2.1 to 4.1) microg/mL vs. 8.6 (6.5 to 11.3) microg/mL], but rose 4-fold postprandially in the obese group, reaching a peak at 60 minutes [baseline: 2.9 (2.1 to 4.1) microg/mL vs. 60 minutes: 12.1 (8.5 to 17.4) microg/mL; p< 0.0001] and remaining elevated for the remainder of the study. There were no postprandial changes in plasma adiponectin concentrations in lean subjects. DISCUSSION: This increase of adiponectin concentrations in obese individuals might have important beneficial effects on postprandial glucose and lipid metabolism and might be viewed as a mechanism for maintaining normal glucose tolerance in those who are obese and insulin resistant.
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English et al. (2003) conducted an observational in Obesity (n=24). Fixed breakfast vs. Lean subjects / Baseline was evaluated on Plasma adiponectin concentrations at 60 minutes (p=<0.0001). A fixed breakfast induced a 4-fold increase in plasma adiponectin at 60 minutes in obese subjects (from 2.9 to 12.1 microg/mL; p<0.0001), with no postprandial changes in lean subjects.