August 1, 1988The Journal of Clinical Endocrinology & Metabolism
Fat Calories May be Preferentially Stored in Reduced-Obese Women: A Permissive Pathway for Resumption of the Obese State*
Key result
Oral corn oil fails to blunt ATLPL response in reduced-obese women unlike in lean controls.
- P<0.02
- n=15
Why the study?
The effect of dietary fat calories on adipose tissue lipoprotein lipase responsiveness in lean, obese, and reduced-obese women and its role in weight regain was unclear.
Does oral corn oil ingestion alter the responsiveness of gluteal adipose tissue lipoprotein lipase to glucose/insulin in lean and reduced-obese women?
Comparison
Euglycemic insulin clamp with oral corn oil ingestion vs without corn oil ingestion
Design
Paired euglycemic insulin clamp studies in each subject
Follow-up
3 months weight maintenance after weight loss
Authors
Discussion
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Implication
May promote weight regain via unblunted ATLPL in reduced-obese women; leaves open differential dietary fat effects on postprandial lipolysis by obesity history.
Structured PICO
Does oral corn oil ingestion alter the responsiveness of gluteal adipose tissue lipoprotein lipase to glucose/insulin in lean and reduced-obese women?
P
Population
15 women (6 lean, 9 moderately obese) undergoing paired euglycemic insulin clamp studies to assess adipose tissue lipoprotein lipase responsiveness before and after weight loss.
I
Intervention
Euglycemic insulin (40 mU/m2.min) clamp with oral corn oil ingestion
C
Comparator
Euglycemic insulin clamp without oral corn oil ingestion
O
Outcome
Responsiveness of gluteal adipose tissue lipoprotein lipase (ATLPL) to glucose/insulinsurrogate
Main Result
Absolute Event Rate: 0.2% vs 3.3%
p-value: p=<0.02
In reduced-obese women, dietary fat fails to blunt the ATLPL response to glucose/insulin, potentially promoting triglyceride deposition and weight regain.
Cite This Study
Yost et al. (1988) studied Obesity (n=15). Oral corn oil ingestion vs. Glucose/insulin alone (no corn oil) was evaluated on Change in gluteal adipose tissue lipoprotein lipase (ATLPL) activity in normal women (p=<0.02). Oral corn oil ingestion failed to blunt the ATLPL response to glucose/insulin in reduced-obese women, unlike in lean women where it significantly diminished responsiveness (P<0.02).