Why the study?
What is the contribution of endothelium-derived hyperpolarizing factor (EDHF) to exercise-induced vasodilation in healthy subjects and those with hypercholesterolemia?
Population
Healthy and hypercholesterolemic subjects
Comparison
Infusions of l-NMMA, tetraethylammonium, and… vs Baseline resting state and comparison between…
Design
Cross-sectional
Authors
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Supports EDHF mediation of exercise vasodilation despite impairment in hypercholesterolemia; hypothesis-generating for targeted interventions.
What is the contribution of endothelium-derived hyperpolarizing factor (EDHF) to exercise-induced vasodilation in healthy subjects and those with hypercholesterolemia?
Exercise-induced vasodilation is impaired and predominantly mediated by EDHF rather than nitric oxide in hypercholesterolemic subjects.
Ozkor et al. (2015) studied this question.
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