Why the study?
Does eprosartan reduce sympathetic activity in young men with normal to mildly hypertensive blood pressure?
Population
29 young white men with normal to mildly hypertensive BP values
Comparison
Eprosartan 600 mg/d for 1 week vs Placebo for 1 week
Design
RCT, randomized cross-over protocol, double-blind
Follow-up
1 week
Authors
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Eprosartan lowers BP yet raises sympathetic activity and norepinephrine; challenges animal-model assumptions and cautions against presuming sympathoinhibition in humans.
Does eprosartan reduce sympathetic activity in young men with normal to mildly hypertensive blood pressure?
Contrary to animal models, AT1 receptor blockade with eprosartan increases sympathetic nerve activity and norepinephrine levels in humans, likely due to baroreflex resetting.
Karsten Heusser (2003) studied this question.
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