Why the study?
The exact mechanisms of Ang-2 action in renal diseases remain unclear, prompting a summary of preclinical and clinical findings to systematically understand its role.
What is the role of Angiopoietin-2 in the pathogenesis and progression of kidney diseases?
What is the role of Angiopoietin-2 in the pathogenesis and progression of kidney diseases?
Angiopoietin-2 is overexpressed in kidney diseases and may serve as a useful biomarker, though its exact mechanistic role requires further elucidation.
Elevated Ang-2 may mark endothelial instability in kidney disease; leaves open whether Ang-Tie2 modulation improves outcomes.
Background: Angiopoietins (Ang) are essential angiogenic factors involved in angiogenesis, vascular maturation, and inflammation. The most studied angiopoietins, angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), behave antagonistically to each other in vivo to sustain vascular endothelium homeostasis. While Ang-1 typically acts as the endothelium-protective mediator, its context-dependent antagonist Ang-2 can promote endothelium permeability and vascular destabilization, hence contributing to a poor outcome in vascular diseases via endothelial injury, vascular dysfunction, and microinflammation. The pathogenesis of kidney diseases is associated with endothelial dysfunction and chronic inflammation in renal diseases. Summary: Several preclinical studies report overexpression of Ang-2 in renal tissues of certain kidney disease models; additionally, clinical studies show increased levels of circulating Ang-2 in the course of chronic kidney disease, implying that Ang-2 may serve as a useful biomarker in these patients. However, the exact mechanisms of Ang-2 action in renal diseases remain unclear. Key Messages: We summarized the recent findings on Ang-2 in kidney diseases, including preclinical studies and clinical studies, aiming to provide a systematic understanding of the role of Ang-2 in these diseases.
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Li et al. (2023) studied this question.
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