Why the study?
Do aspirin and indomethacin alter exercise-induced changes in blood pressure and limb blood flow in normal volunteers?
Do aspirin and indomethacin alter exercise-induced changes in blood pressure and limb blood flow in normal volunteers?
Aspirin and indomethacin have different effects on exercise-induced blood pressure changes but similarly attenuate exercise-induced increases in limb blood flow in normal volunteers.
Answers are grounded in this paper and cite their sources.
May warrant preferring aspirin over indomethacin for exercise BP stability in active patients; extends evidence distinguishing NSAID effects on hemodynamics.
To evaluate the possible role of prostaglandins in exercise-induced changes in blood pressure and limb blood flow we have compared the effects of aspirin and indomethacin in a double-blind placebo controlled study in a group of normal volunteers. Nine men undertook treadmill exercise after pretreatment with placebo, aspirin and indomethacin. Indomethacin caused a greater increase in systolic blood pressure during exercise than aspirin (p less than 0.05) and a smaller fall in diastolic pressure than either placebo or aspirin (p less than 0.02 and p less than 0.01). Compared with placebo both aspirin and indomethacin attenuated to a similar degree the increase in calf blood flow (p less than 0.05 and p less than 0.03) and the changes in forearm blood flow following exercise. These results suggest that although aspirin and indomethacin both inhibit prostaglandin production they have different effects on exercise-induced changes in blood pressure. They have, however, similar effects on limb blood flow.
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Cowley et al. (1985) studied this question.
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