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Does indomethacin pretreatment alter the reduction in forearm blood flow induced by propranolol in healthy subjects?
Does indomethacin pretreatment alter the reduction in forearm blood flow induced by propranolol in healthy subjects?
Indomethacin pretreatment does not augment the reduction in forearm blood flow induced by propranolol in healthy subjects.
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Indomethacin pretreatment does not modify propranolol's forearm blood flow effects; confirms no interaction and supports safe co-administration in this model.
The influence of indomethacin on a reduction in forearm blood flow (FBF) induced by propranolol was investigated in eight healthy subjects. Indomethacin was orally administered (75 mg daily for 3 days) in a randomized cross-over design. Blood pressure (BP) was slightly decreased after a single oral administration of propranolol (40 mg) alone. However BP was slightly increased after the drug with indomethacin pretreatment. FBF was significantly decreased after propranolol with or without indomethacin. No significant difference was observed in FBF before or after propranolol between both groups. Plasma renin activity (PRA) was reduced by indomethacin pretreatment. These results suggest that the reduction in FBF induced by propranolol is not augmented with indomethacin.
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Sugimoto et al. (1989) studied this question.
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