Key result
Indoramin and propranolol alone or combined blunt cardiovascular responses to cold in hypertensives versus placebo.
Why the study?
The cardiovascular responses to cold exposure in hypertensive patients and the effects of indoramin and propranolol on these responses were not fully characterized.
Do indoramin and propranolol attenuate cardiovascular responses to cold in hypertensive patients?
RCT (n=9)
Do indoramin and propranolol attenuate cardiovascular responses to cold in hypertensive patients?
Indoramin and propranolol, alone or in combination, attenuate the cardiovascular pressor response to cold in hypertensive patients.
Answers are grounded in this paper and cite their sources.
May blunt cold-induced pressor responses in hypertension; leaves open clinical utility pending larger trials.
Immersion of the hand into ice water (cold-pressor test) in nine hypertensive subjects induced elevation of mean blood pressure, increase of vascular resistance in the extremities, decrease of blood flow in the extremities, and increase in heart rate. The preejection phase of systole was not altered. Indoramin and propranolol, each alone and together, attenuated the pressor and other cardiovascular responses. Submaximal exercise increased heart rate during placebo treatment, a response only partially attenuated by indoramin, propranolol, and their combination, but it did not induce changes in mean blood pressure during any of the treatments.
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Velasco et al. (1982) conducted an RCT in Hypertension (n=9). Indoramin and propranolol vs. Placebo was evaluated on Cardiovascular response to cold (mean blood pressure, vascular resistance, heart rate). Indoramin and propranolol, alone and in combination, attenuated the pressor and other cardiovascular responses to cold in hypertensive subjects compared to placebo.
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