Why the study?
Does indoramin reduce blood pressure in patients with moderate to severe essential hypertension?
Population
25 patients with moderate to severe essential hypertension
Comparison
Indoramin 100 mg to 200 mg per day over 4 weeks vs Placebo
Design
RCT, double-blind
Follow-up
4 weeks
Authors
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Indoramin achieves large BP reductions in moderate-severe hypertension; confirms alpha-1 blockade efficacy as monotherapy.
Does indoramin reduce blood pressure in patients with moderate to severe essential hypertension?
Indoramin is an effective alpha-blocker for significantly reducing blood pressure in moderate to severe essential hypertension.
Faerchtein et al. (1976) studied this question.